MABF213

Anti- STING, clone 41 Antibody

clone 41, 0.5 mg/mL, from rat

• Synonyme(s) : Stimulator of interferon genes protein, mSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA, Transmembrane protein 173, STING
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rat
• Niveau de qualité: 100
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: 41, monoclonal
• Espèces réactives: mouse
• Concentration: 0.5 mg/mL
• Technique(s): flow cytometry: suitable; western blot: suitable
• Isotype: IgMκ
• Numéro d'accès NCBI: NP_082537
• Numéro d'accès UniProt: Q3TBT3
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: mouse ... Sting1(72512)

Description

Description générale

STING, also known as mSTING, or Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA or Transmembrane protein 173, and encoded by the gene Tmem 173/Eris/Mita/Mpys/Sting, is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferons. STING acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol. Upon binding STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. STING also mediates cell death signaling via the activation of the ERK pathway. STING is found in multiple intracellular locations including the endoplasmic reticulum, plasma cell membrane, mitochondrion outer membrane, and perinuclear regions. STING is expressed in the B-cell lineage both immature and mature B cells but not plasma cells. Mutations in STING cause defects in innate immunity and compromised immune health.

Immunogène

Recombinant protein corresponding to the cytoplasmic domain of mouse STING.

Application

Analyse par cytométrie en flux : µ

This Anti- STING, clone 41 Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of STING.

Qualité

Produit évalué par western blotting sur lysat de cellules RAW264.7.

Analyse par western blotting : µ

Description de la cible

Poids réel (observé) : env. 42 kDa. Uniprot décrit 2 isoformes produites par un épissage alternatif à env. 38 kDa et env. 48 kDa

Forme physique

Format : Produit purifié

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable