ABT22

Anti-Endophilin-A1 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : SH3-domain GRB2-like 2, bA335L15.1 (SH3-domain GRB2-like 2), Endophilin A1 BAR domain, SH3 domain protein 2A, Endophilin-1, SH3 domain-containing GRB2-like protein 2
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: mouse, rat
• Technique(s): western blot: suitable
• Isotype: IgG
• Numéro d'accès NCBI: NP_062408
• Numéro d'accès UniProt: Q62420
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: mouse ... Sh3Gl2(20404)

Description

Description générale

A member of the Endophilin family, Endophilin A1 is a protein containing SH3 domains, and has been implicated in the trafficking of clathrin-mediated synaptic vesicle endocytosis within the membrane. It was originally characterized as a presynaptically enriched protein that binds to endocytic proteins polyphosphoinositide synaptojanin and dynamin. Endophilin A1 has been implicated in endocytic vesicle budding when its function in cell-free systems and in living synapses has been disturbed. Along with the SH3 domain, Endophilin A1 contains a BAR domain in the N-terminal region, that has been found to induce and bind membrane curvature. This protein’s expression is localized to the brain, most specifically in the frontal cortex. Markedly high expression is observed in fetal cerebellum.

Spécificité

Human (94% sequence homology).

The antibody recognizes Endophilin-A1.

Immunogène

KLH-conjugated linear peptide corresponding to mouse Endophilin-A1.

Application

This Anti-Endophilin-A1 Antibody is validated for use in WB for the detection of Endophilin-A1.

Western Blot Analysis: 1:500 dilution from a previous lot detected Endophilin-A1 in 10 µg of rat brain and mouse brain membrane tissue lysates.

Qualité

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected Endophilin-A1 in 10 µg of mouse brain tissue lysate.

Description de la cible

~ 42 kDa

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable