ABC337

Anti-BAFF receptor Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, CD268
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41
• Clone: polyclonal
• application: IHC; WB
• Espèces réactives: rat, human, mouse
• Technique(s): immunohistochemistry: suitable; western blot: suitable

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: rat, human, mouse
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Numéro d'accès UniProt: Q96RJ3
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... TNFRSF13C(115650)

Description

Description générale

B-cell-activating factor receptor (BAFF receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and BLyS receptor 3 (BR3), is a member of the TNF superfamily that regulate immune responses and induce apoptosis. BAFF receptor promotes the survival of mature B-cells and the B-cell response. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase. BAFF receptor is highly expressed in spleen and lymph node, with lower levels found in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. Mutations in BAFF receptor have been associated with immunodeficiency common variable type 4 (CVID4), also called BAFFR defect.

Spécificité

This antibody recognizes the C-terminus of BAFF receptor.

Immunogène

KLH-conjugated linear peptide corresponding to the C-terminus of human BAFF receptor.

Application

Detect B-cell-activating factor receptor using this rabbit polyclonal antibody, Anti-BAFF receptor Antibody validated for use in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected BAFF receptor in human tonsil tissue.

Qualité

Evaluated by Western Blotting in human, mouse, and rat spleen tissue lysates.

Western Blotting Analysis: 5 µg/mL of this antibody detected BAFF receptor in 15 µg of human, mouse, and rat spleen tissue lysates.

Description de la cible

~22 kDa observed. Uniprot describes two isoforms at ~19 kDa Uncharacterized bands may appear in some lysates.

Remarque sur l'analyse

Control
Human, mouse, and rat spleen tissue lysates

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable