553211
Rapamycin
≥95% (HPLC), solution, mTOR inhibitor, Calbiochem
Synonyme(s) :
InSolution Rapamycin, mTOR Inhibitor I
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About This Item
Formule empirique (notation de Hill):
C51H79NO13
Poids moléculaire :
914.17
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Produits recommandés
product name
Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
Niveau de qualité
Pureté
≥95% (HPLC)
Forme
solution
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
desiccated (hygroscopic)
protect from light
Conditions d'expédition
wet ice
Température de stockage
−20°C
Description générale
Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
Actions biochimiques/physiologiques
Cell permeable: no
Primary Target
Mammalian target of rapamycin (mTOR)
Mammalian target of rapamycin (mTOR)
Product does not compete with ATP.
Reversible: no
Target IC50: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Irritant (B)
Forme physique
2.5 mg/mL solution in DMSO (2.74 mM)
Reconstitution
Following initial use, aliquot and freeze (-20°C).
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Point d'éclair (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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Human adipose-derived stem cells (ASCs) show immense promise for treating inflammatory diseases, attributed primarily to their potent paracrine signaling. Previous investigations demonstrated that short-term Rapamycin preconditioning of bone marrow-derived stem cells (BMSCs) elevated secretion of prostaglandin E2, a pleiotropic molecule
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Intestinal intraepithelial lymphocytes (IEL) are an abundant population of tissue-resident T cells that protect and maintain the intestinal barrier. IEL respond to epithelial cell-derived IL-15, which is complexed to the IL-15 receptor α chain (IL-15/Rα). IL-15 is essential both for
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