538904

Prostaglandin E₂

Involved in vasodilator actions of kinins such as bradykinin.

• Synonyme(s) : Prostaglandin E₂, PGE₂
• Formule empirique (notation de Hill): C₂₀H₃₂O₅
• Numéro CAS: 363-24-6
• Poids moléculaire : 352.47
• Numéro MDL: MFCD00077861
• Code UNSPSC : 12352211

Propriétés

• Niveau de qualité: 100
• Pureté: >98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white to light yellow
• Solubilité: acetone: soluble; ethanol: soluble; ethyl acetate: soluble; methanol: soluble
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• InChI: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+
• Clé InChI: XEYBRNLFEZDVAW-RTYMFESYSA-N

Description

Description générale

Involved in vasodilator actions of kinins such as bradykinin. Inhibits MAP kinase in rat mesangial cells (IC₅₀ = 25-50 µM). Regulates the activity of adenylate cyclase via G-protein coupled receptors.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Involved in vasodilator actions of kinins such as bradykinin

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 25-50 µM inhibiting MAP kinase in rat mesangial cells

Avertissement

Toxicity: Harmful (C)

Autres remarques

Li, X., et al. 1995. Am. J. Physiol.269, C986.
Kessler, W., et al. 1992. Exp. Brain Res.91, 467.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H302 - H360FD
• Conseils de prudence: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classification des risques: Acute Tox. 4 Oral - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3