5.08161

SNC80

• Synonyme(s) : SNC80, δ Opioid Receptor Agonist, SNC80
• Formule empirique (notation de Hill): C₂₈H₃₉N₃O₂
• Numéro CAS: 156727-74-1
• Poids moléculaire : 449.63
• Numéro MDL: MFCD00672673
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Puissance: 0.32 μM IC₅₀
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: cream
• Solubilité: 1 M HCl: 100 mM; DMSO: 20 mM
• Température de stockage: −20°C
• InChI: 1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
• Clé InChI: KQWVAUSXZDRQPZ-UMTXDNHDSA-N

Description

Description générale

A very potent and selective δ opioid receptor agonist (IC₅₀ = 0.32 µM). Shown to induce dose- and time-dependent antinociception after i.c.v., i.th. and i.p. administration in mice. Widely used in studies of depression and inflammatory injuries. It is also reported to be acted upon heteromeric u-d receptors.

Actions biochimiques/physiologiques

Primary Target
Dela opioid receptor

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Pradhan, A., et al., 2013. Mol Pain.9, 8.
Saitoh, A., et al., 2012. Curr. Neuropharmacol.10, 231.
Metcalf. M. et al. 2012. ACS Chem. Neurosci.3, 505.
Bilsky, J., et al. 1995. J. Pharmacol. Exp. Ther.273, 359.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable