5.04914

CNQX

• Synonyme(s) : CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
• Formule empirique (notation de Hill): C₉H₄N₄O₄
• Numéro CAS: 115066-14-3
• Poids moléculaire : 232.15
• Numéro MDL: MFCD00069232
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white to yellow
• Solubilité: DMSO: 25 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
• Clé InChI: RPXVIAFEQBNEAX-UHFFFAOYSA-N

Description

Description générale

A potent and competitive antagonist for AMPA/kainate receptors (K_i = 0.6 - 2.11 µM for GluA1-4 and K_i = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

A potent and competitive antagonist for AMPA/kainate receptors (K_i = 0.6 - 2.11 µM for GluA1-4 and K_i = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Actions biochimiques/physiologiques

Secondary Target
Kainate

Target K_i: 0.6 – 2.11 →M for GluA1 – 4 and Ki

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
King, A., et al. 1992. Br. J. Pharmacol.107, 375.
Long, S. et al. 1990. Br. J. Pharmacol.100, 850.Harris, K., et al. 1989. Brain Res.5, 185Honore, T., et al. 1988. Science.241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol.156, 177.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable