483125-M

N^G-Nitro-L-arginine Methyl Ester, Hydrochloride

Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

• Synonyme(s) : N^G-Nitro-L-arginine Methyl Ester, Hydrochloride, N ^ω-NO₂-L-Arg-OMe, N ^G-NO₂-L-Arg-OMe, L-NAME, HCl, N^ω-NO₂-L-Arg-OMe, N^G-NO₂-L-Arg-OMe, L-NAME, HCl
• Formule empirique (notation de Hill): C₇H₁₅N₅O₄ · xHCl
• Numéro CAS: 51298-62-5
• Poids moléculaire : 233.23 (free base basis)
• Numéro MDL: MFCD00039052
• Code UNSPSC : 12352209

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: white to off-white
• Solubilité: water: 50 mg/mL
• Température de stockage: −20°C
• InChI: 1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
• Clé InChI: QBNXAGZYLSRPJK-JEDNCBNOSA-N

Description

Description générale

Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

Actions biochimiques/physiologiques

Primary Target
eNOS

Target IC₅₀: 500 nM against eNOS

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Autres remarques

Baylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA88, 6368.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Moore, P.K., et al. 1990. Br. J. Pharmacol.99, 408.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable