P6126

(R)-(−)-Phenylephrine hydrochloride

≥99% (titration), powder, α₁-adrenoceptor agonist

• Synonyme(s) : (R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride, (R)-(−)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride
• Formule linéaire : HOC₆H₄CH(CH₂NHCH₃)OH·HCl
• Numéro CAS: 61-76-7
• Poids moléculaire : 203.67
• Numéro Beilstein : 4158948
• Numéro CE : 200-517-3
• Numéro MDL: MFCD00012605
• Code UNSPSC : 12352200
• ID de substance PubChem : 57654535
• Nomenclature NACRES : NA.77

Propriétés

• product name: (R)-(−)-Phenylephrine hydrochloride, powder
• Forme: powder
• Pf: 143-145 °C (lit.)
• Auteur: Johnson & Johnson
• Chaîne SMILES: OC1=CC([C@H](CNC)O)=CC=C1.Cl
• InChI: 1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
• Clé InChI: OCYSGIYOVXAGKQ-FVGYRXGTSA-N
• Informations sur le gène: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Description

Description générale

(R)-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug.

Application

(R)-(-)-Phenylephrine hydrochloride has been used:

• in the preparation and culturing of cardiocytes and fibroblasts
• to stimulate myocardial strips to measure slice contraction
• in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo
• to evaluate the pharmacological response of embryonic stem cell (ESC)-derived cardiomyocytes
• to pharmacologically rescue GATA (erythroid transcription factor) binding protein 3 (GATA3) null embryo from early embryonic lethality

Actions biochimiques/physiologiques

α₁-adrenoceptor agonist.

Caractéristiques et avantages

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H317
• Conseils de prudence: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Classification des risques: Acute Tox. 4 Oral - Skin Sens. 1B
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves