444287

MMP-13, Human, Recombinant, Active

• Synonyme(s) : Matrix metalloproteinase 13
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Forme: liquid
• Niveau de qualité: 100
• Activité spécifique: ≥50 mU/mg protein
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles
• Conditions d'expédition: wet ice
• Température de stockage: −70°C

Description

Description générale

Recombinant, human MMP-13. MMP-13 is a collagenase-3 enzyme that degrades a range of extracellular matrix proteins, including collagen types I, II, III, IV, IX, X, and XIV, gelatin, aggrecan, perlecan and fibronectin. It is distinguished from other human collagenases by the fact that it effectively degrades type II collagen. The importance of MMP-13 is further strengthened by reports that it is a biomarker for poor prognosis in many carcinomas and other type of cancers.

Conditionnement

Please refer to vial label for lot-specific concentration.

Avertissement

Toxicity: Standard Handling (A)

Définition de l'unité

One unit is defined as the amount of APMA-activated enzyme that will hydrolyze 1µmol MCA-Pro-Leu-Lys-Gly-Leu-DPA-Ala-Arg-NH₂ (Cat. No. 03-32-5032) at 37°C, pH 7.5.

Forme physique

In 50 mM HEPES, 10 mM CaCl₂, 20% glycerol, 0.005% BRIJ^® 35 Detergent, pH 7.5. APMA-free.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Autres remarques

Freije, M.P.S., et al. 1994. J. Biol. Chem.269,16766.

Informations légales

Brij is a registered trademark of Croda International PLC

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable