420321

KT5823

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

• Synonyme(s) : KT5823, PKG Inhibitor VII
• Formule empirique (notation de Hill): C₂₉H₂₅N₃O₅
• Numéro CAS: 126643-37-6
• Poids moléculaire : 495.53
• Numéro MDL: MFCD09878278
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 1 mg/mL; DMF: soluble
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
• Clé InChI: QTYMDECKVKSGSM-YMUMJAELSA-N

Description

Description générale

Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM). Inhibits protein kinase C (K_i = 4.0 µM) and protein kinase A (K_i >10.0 µM) at higher concentrations.

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
PKG

Product competes with ATP.

Reversible: yes

Target K_i: 234 nM against protein kinase G

Avertissement

Toxicity: Standard Handling (A)

Notes préparatoires

Further dilute with aqueous buffers just prior to use.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Grider, J.R. 1993. Am. J. Physiol.264, G334.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable