370654

PKG Inhibitor

The PKG Inhibitor controls the biological activity of PKG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : PKG Inhibitor, Protein Kinase G Inhibitor, RKRARKE
• Formule empirique (notation de Hill): C₃₈H₇₄N₁₈O₁₀
• Poids moléculaire : 943.11
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Solubilité: water: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A more specific, reversible, and substrate competitive inhibitor of protein kinase G (K_i = 86 µM) relative to protein kinase A (K_i = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser³² to Ala³²) of histone H2B (amino acids 29-35).

A specific, reversible, and substrate competitive inhibitor of PKG (K_i = 86 µM) relative to PKA (K_i = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser³² to Ala³²) of histone H2B (amino acids 29-35).

Actions biochimiques/physiologiques

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target K_i: 86 µM against protein kinase G

Conditionnement

Yes

Avertissement

Toxicity: Standard Handling (A)

Séquence

H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH

Autres remarques

Glass, D.B., et al. 1983. Biochem. J.213, 159.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable