14-595-M

PP1α Protein, 10 µg

Recombinant, full length, human PP1α, for use in Phosphatase Assays.

• Synonyme(s) : PPP1C, Phosphoprotein phosphatase 1, Phosphorylase phosphatase
• Code UNSPSC : 12352200
• eCl@ss : 32160405
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Niveau de qualité: 100
• Produit recombinant: expressed in E. coli
• Forme: solution
• Durée de conservation: 6 mo.
• Poids mol.: M_w 37.6 kDa
• Fabricant/nom de marque: Upstate^®
• Technique(s): activity assay: suitable (phosphatase)
• Solubilité: water: soluble
• Numéro d'accès NCBI: NM_001008709.1; NM_002708.3; NM_206873.1
• Numéro d'accès UniProt: P62136
• Température de stockage: −20°C
• Informations sur le gène: human ... PPP1CA(5499)

Description

Description générale

Research area: Neuroscience
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.

Application

Research Category
Inflammation & Immunology

Actions biochimiques/physiologiques

Protein Target: PP1α Target Sub-Family: Ser/Thr phosphatase

Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.

Conditionnement

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.

Qualité

routinely evaluated by dephosphorylation of 100μM DiFMUP

Forme physique

Heparin agarose followed by Q agarose

Stockage et stabilité

6 months at -20°C from date of shipment

Autres remarques

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317
• Conseils de prudence: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classification des risques: Skin Sens. 1
• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1