810603C

16:0-10 Doxyl PC

Avanti Polar Lipids 810603C

• Synonyme(s) : 1-palmitoyl-2-stearoyl-(10-doxyl)-sn-glycero-3-phosphocholine
• Formule empirique (notation de Hill): C₄₆H₉₀N₂O₁₀P
• Numéro CAS: 188004-25-3
• Poids moléculaire : 862.19
• Code UNSPSC : 41141825

Propriétés

• Pureté: >99% (TLC)
• Forme: liquid
• Conditionnement: pkg of 1 × 1 mL (810603C-1mg)
• Fabricant/nom de marque: Avanti Polar Lipids 810603C
• Concentration: 1 mg/mL (810603C-1mg)
• Type de lipide: ESR probes; phospholipids
• Conditions d'expédition: dry ice
• Température de stockage: −20°C

Description

Description générale

Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.

Phosphocholine is considered as a precursor molecule. It is formed during the breakdown of phosphatidylcholine metabolism.

Application

16:0-10 Doxyl PC may be used in vesicles for quenching PT-(1–46)F4W fluorescence. It may also be used in vesicles to check the fluorescence emission spectra in order to measure the penetration depth of the peptides′ tryptophan residues in lipid bilayer.

Actions biochimiques/physiologiques

Phosphatidylcholine (PC) lowers the levels of cholesterol and triglycerides.

Conditionnement

5 mL Clear Glass Sealed Ampule (810603C-1mg)

Notes préparatoires

Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 - H412
• Conseils de prudence: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): does not flash
• Point d'éclair (°C): does not flash