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Sigma-Aldrich

KitAlysis High-Throughput Miyaura Borylation Reaction Screening Kit-Pack of 2

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About This Item

Code UNSPSC :
12161600
Nomenclature NACRES :
NA.21

Pertinence de la réaction

reagent type: catalyst
core: palladium
reaction type: Miyaura Borylation Reaction

Groupe fonctionnel

phosphine

Description générale

The KitAlysis High-Throughput Miyaura Borylation Reaction Screening Kit enables chemists to quickly and efficiently screen reaction conditions for Pd catalyzed Miyaura borylation reactions. Quick identification of optimal conditions allows faster scale-up of the desired synthetic transformation. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.
Step-by-Step Guide for Miyaura Borylation Reaction Screening Kit
Downloadable Experiment excel sheets

Each kit contains 2 customizable screening sets that include the following components:

  • 6 x 4 pre-weighed catalysts in glass vials loaded with stir bars and topped with cap mat.
  • 4 x 4 mL reaction vials with pre-weighed KOAc
  • Bis(pinacolato)diboron (473294), tetrahydroxydiboron (754242), and pinacol (221171)
  • 1 (2 mL) ampule each of toluene, THF, n-butanol, DMA, MeOH, MeCN, ethylene glycol and DIPEA.
  • 1 NEW KitAlysis 24-Well Reaction Block Replacement Film.
  • 4 stir bars for substrate stock solution vials.
  • 1 internal standard.
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Caractéristiques et avantages

  • Designed and tested by synthetic chemists.
  • Easily run 24-microscale reactions in parallel.
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration.
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks.

Informations légales

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Composants de kit également disponibles séparément

Réf. du produit
Description
FDS

  • 764175P(Cy3) Pd G3, 97%FDS

  • 791733Potassium acetate, anhydrous, free-flowing, Redi-Dri, ACS reagent, ≥99.0%FDS

  • 804274XPhos Pd G4, 95%FDS

  • 804282SPhos Pd G4FDS

  • 804290RuPhos Pd G4FDS

  • 804975DTBPF-Pd-G3FDS

  • 900349cataCXium Pd G4FDS

  • 900522Toluene, anhydrous, ZerO2®, 99.8%FDS

  • 900631Ethylene glycol, anhydrous, ZerO2®, 99.8%FDS

  • 900634N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8%FDS

  • 900636Tetrahydrofuran, anhydrous, inhibitor-free, ZerO2®, ≥99.9%FDS

  • 9006391-Butanol, anhydrous, ZerO2®, 99.8%FDS

  • 900641Methanol, anhydrous, ZerO2®, 99.8%FDS

  • 900644Acetonitrile, anhydrous, ZerO2®, 99.8%FDS

  • 900690N,N-Diisopropylethylamine, purified by redistillation, ZerO2®, 99.5%FDS

  • 221171Pinacol, 98%FDS

  • 473294Bis(pinacolato)diboron, 99%FDS

  • 754242Tetrahydroxydiboron, 95%FDS

  • B34656Biphenyl, ReagentPlus®, 99.5%FDS

  • Z118850Spinbar® magnetic stirring fleas, red, L 10 mm, diam. 3 mmFDS

  • Z742110KitAlysis 24-well reaction block replacement filmFDS

Afficher tout (21)

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Oral - STOT SE 1 - STOT SE 3

Organes cibles

Central nervous system, Eyes,Central nervous system, Kidney, Respiratory system

Risques supp

Code de la classe de stockage

3 - Flammable liquids

Point d'éclair (°F)

1.4 °F

Point d'éclair (°C)

-17 °C


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Articles

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

Protocoles

Catalyst screening, KitAlysis™ High-Throughput Screening Kits, Thin layer chromatography (TLC), parallel analysis, parallel synthesisigh-Throughput Buchwald-Hartwig Amination Reaction Screening Kit, TLC-MS analysis

Contenu apparenté

La conception et l'optimisation d'une réaction chimique en synthèse organique vise à altérer avec précision certains paramètres de la réaction pour obtenir des résultats optimaux dans la recherche de voies menant aux molécules cibles.

Chemical reaction design and optimization in organic synthesis aims to precisely alter reaction parameters to achieve optimum results in finding pathways to target molecules.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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