773069

Fmoc-N-Me-Cys(Trt)-OH

97% (HPLC)

• Synonyme(s) : N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine
• Formule empirique (notation de Hill): C₃₈H₃₃NO₄S
• Numéro CAS: 944797-51-7
• Poids moléculaire : 599.74
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.26

Propriétés

• Pureté: 97% (HPLC)
• Forme: powder or crystals
• Activité optique: [α]22/D -25.0°, c = 0.5% in dichloromethane
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Pf: 234-239 °C
• Application(s): peptide synthesis
• Groupe fonctionnel: Fmoc
• Température de stockage: 2-8°C
• InChI: 1S/C38H33NO4S/c1-39(37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34)35(36(40)41)26-44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29/h2-24,34-35H,25-26H2,1H3,(H,40,41)/t35-/m0/s1
• Clé InChI: RAKOPMQMPUNRGI-DHUJRADRSA-N

Description

Application

Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine).
It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable