142662

Chlorosulfonyl isocyanate

98%

• Synonyme(s) : CSI
• Formule linéaire : ClSO₂NCO
• Numéro CAS: 1189-71-5
• Poids moléculaire : 141.53
• Numéro Beilstein : 1237247
• Numéro CE : 214-715-2
• Numéro MDL: MFCD00011608
• Code UNSPSC : 12352100
• ID de substance PubChem : 24848531
• Nomenclature NACRES : NA.22

Propriétés

• Pression de vapeur: 5.57 psi ( 20 °C)
• Niveau de qualité: 200
• Pureté: 98%
• Forme: liquid
• Indice de réfraction: n20/D 1.447 (lit.)
• Point d'ébullition: 107 °C (lit.)
• Pf: −44 °C (lit.)
• Densité: 1.626 g/mL at 25 °C (lit.)
• Température de stockage: 2-8°C
• Chaîne SMILES: ClS(=O)(=O)N=C=O
• InChI: 1S/CClNO3S/c2-7(5,6)3-1-4
• Clé InChI: WRJWRGBVPUUDLA-UHFFFAOYSA-N
• Informations sur le gène: human ... ABCB1(5243) , FPR1(2357)

Description

Description générale

Chlorosulfonyl isocyanate is classified as an isocyanate and is widely used as a reagent in sulfonylation and carbamoylation reactions.Chlorosulfonyl isocyanate reacts with hydrocarbon alkenes via stepwise dipolar pathway to give N-chlorosulfonyl-β-lactams.

Application

• Chlorosulfonyl isocyanate was used in synthesis and biochemical characterization of new class of membrane-associated glycosyltransferase inhibitors.
• It is synthetically versatile reagent and was used in the preparation of amides, lactams and triazocinones.
• It was employed in regio- and diastereoselective introduction of a protected amino group in synthesis of chiral, polyhydroxylated piperidines.
• It was used as reagent during the synthesis of novel sulfamides.

Employed in a regio- and diastereoselective introduction of a protected amino group in a synthesis of chiral, polyhydroxylated piperidines. Generation of ureas from amino groups in a synthesis of benzimidazolones.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H314,H317,H334
• Conseils de prudence: P261 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Risques supp: EUH014
• Code de la classe de stockage: 8A - Combustible corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): >230.0 °F
• Point d'éclair (°C): > 110 °C
• Équipement de protection individuelle: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter