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Key Documents

SCP0207

Sigma-Aldrich

PTH Peptide

≥95% (HPLC), lyophilized powder, bovine, 1-34

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About This Item

Empirical Formula (Hill Notation):
C185H293N55O50
Molecular Weight:
4087.64
UNSPSC Code:
12352209
NACRES:
NA.32

product name

[Nle8,18,Tyr34]-PTH 1-34 bovine,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥72%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Ala-Val-Ser-Glu-Ile-Gln-Phe-Nle-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Nle-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2

Application

Parathyroid hormone (PTH) is an 84 amino acid hormone involved in calcium regulation in counteraction to calcitonin. PTH regulates serum phosphate levels and vitamin D biosynthesis. N-terminal peptides of PTH are used to elicit and study a wide variety of responses in target cells. PTH N-terminal peptides include: PTH (1-34); [Nle8,18,Tyr34]-PTH 1-34; PTH (2-34); [Nle8,18,Tyr34]-PTH (2-34); PTH (3-34); [Nle8,18,Tyr34]-PTH (3-34); PTH (4-34) and PTH (5-34).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Estelle N Bianchi et al.
Bone, 45(4), 716-725 (2009-06-30)
Interaction of the cytoplasmic adaptor molecule beta-arrestin2 with the activated parathyroid hormone (PTH)/PTHrP receptor inhibits G protein mediated signaling and triggers MAPKs signaling. In turn, the effects of both intermittent (i.) and continuous (c.) PTH on bone are altered in

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