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Key Documents

SAB4504299

Sigma-Aldrich

Anti-phospho-Casein Kinase II α (pTyr255) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 45 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

P68400

UniProt accession no.

P68400

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr255)

Gene Information

human ... CSNK2A1(1457)

General description

Casein kinase II α(CK2) is a pleiotropic serine/threonine kinase, that is located on human chromosome 16p13. 2-p13. 3.

Immunogen

The antiserum was produced against synthesized peptide derived from human Casein Kinase II alpha around the phosphorylation site of Tyr255.

Immunogen Range: 221-270

Biochem/physiol Actions

Casein kinase II α(CK2) regulates T-cell polarization by initiating the activation of dendritic cells. CK2 participates in the development of breast carcinoma. Mutations in CK2 results in neurodevelopmental abnormalities and dysmorphic features. This protein induces prosurvival and proinflammatory signaling pathways.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Assignment of the human casein kinase II [alpha][prime] subunit gene (CSNK2A1) to chromosome 16p13. 2-p13. 3
Yang-Feng TL, et al.
Genomics, 19(1) (1994)
De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features
Okur V, et al.
Human Genetics, 135(7), 699-705 (2016)
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients
Bae JS, et al.
The American Journal of Pathology, 186(12), 3297-3315 (2016)
Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation
Gibson SA, et al.
Journal of Immunology, 198(11), 4244-4254 (2017)
Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers
de Bourayne M, et al.
Journal of Leukocyte Biology, 101(3), 703-715 (2017)

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