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F6020

Sigma-Aldrich

Fenofibrate

≥99% (TLC), powder, lipid regulating drug

Synonym(s):

2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester

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About This Item

Empirical Formula (Hill Notation):
C20H21ClO4
CAS Number:
49562-28-9
Molecular Weight:
360.83
EC Number:
256-376-3
MDL number:
MFCD00133314
UNSPSC Code:
12352200
PubChem Substance ID:
24278015
NACRES:
NA.77

product name

Fenofibrate, ≥99%, powder

Quality Level

100

Assay

≥99%

form

powder

color

off-white

originator

Abbott

storage temp.

room temp

SMILES string

CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2

InChI

1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

InChI key

YMTINGFKWWXKFG-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

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Application

Fenofibrate has been used:
  • to study its effect on plasma lipids, liver phenotype and gene expression
  • to study its impact on endothelium-dependent vasodilatation of thoracic aorta
  • to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect

Biochem/physiol Actions

Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H373

Precautionary Statements

P260 - P314 - P501

Hazard Classifications

STOT RE 2 Oral

Target Organs

Liver

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates
Shiri-Sverdlov R, et al.
Journal of Hepatology, 44(4), 732-741 (2006)
Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
Wouters K, et al.
Febs Letters, 584(5), 1001-1005 (2010)
Oshri Avraham et al.
eLife, 10 (2021-09-30)
Sensory neurons with cell bodies in dorsal root ganglia (DRG) represent a useful model to study axon regeneration. Whereas regeneration and functional recovery occurs after peripheral nerve injury, spinal cord injury or dorsal root injury is not followed by regenerative
Kristiaan Wouters et al.
FEBS letters, 584(5), 1001-1005 (2010-02-02)
Hepatic inflammation is the key factor in non-alcoholic steatohepatitis (NASH) and promotes progression to liver damage. We recently identified dietary cholesterol as the cause of hepatic inflammation in hyperlipidemic mice. We now show that hepatic transcriptome responses are strongly dependent
Fenofibrate
Keating GM and Croom KF
Drugs, 67(1), 121?153-121?153 (2012)
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