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344M-9

Sigma-Aldrich

Tyrosinase (T311) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

T311, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (344M-94)
vial of 0.5 mL concentrate (344M-95)
bottle of 1.0 mL predilute (344M-97)
vial of 1.0 mL concentrate (344M-96)
bottle of 7.0 mL predilute (344M-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG2a

control

melanoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... TYR(7299)

Related Categories

General description

Tyrosinase is an enzyme, amongst a family of enzymes, which is involved in the biosynthesis of melanin. Anti-tyrosinase has been found to be quite specific for melanotic lesions such as malignant melanoma and melanotic neurofibroma. Essentially no carcinomas express this marker.

Quality


IVD
IVD
IVD
RUO

Linkage

Tyrosinase Positive Control Slides, Product No. 344S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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C B Meije et al.
The Journal of pathology, 190(5), 572-578 (2000-03-23)
The in situ expression of antigens associated with melanosomes (gp-100), pigmentation (PAA), tyrosinase (TRP-1), melanoma (MAA-1/MAA-2), and HLA-DR was investigated immunohistochemically in frozen archival specimens of common acquired melanocytic naevi, in dysplastic melanocytic naevi, and in lymph node metastases of
Nele Jaanson et al.
Melanoma research, 13(5), 473-482 (2003-09-27)
Tyrosinase, the critical enzyme in melanin synthesis, is also found to be expressed in most malignant melanomas and can serve as a target for the immune response by both CD4+ and CD8+ T-cells. Therefore it could be used as a
Grant E Eudy et al.
Human pathology, 34(8), 797-802 (2003-09-25)
Sentinel lymph node (SLN) biopsy is performed on patients with malignant melanoma (MM) to assess the need for selective complete lymphadenectomy. Melanoma metastasis to regional lymph nodes is an important prognostic indicator in patients with MM. This study assesses the
Jean Kanitakis et al.
The American Journal of dermatopathology, 24(6), 498-501 (2002-11-28)
Trichoblastomas (TBs) are benign skin tumors recapitulating the differentiation of hair follicles. Several pathologic variants have been described, including the rare pigmented TB. We report a deeply pigmented nodular tumor excised on the scalp of a 32-year-old African woman, which
K J Busam et al.
The American Journal of dermatopathology, 22(3), 237-241 (2000-06-28)
Histiocytic tumors can be confused with melanocytic nevi and malignant melanoma and vice versa. To explore the use of immunohistochemistry for this diagnostic problem, we examined the expression of S-100 protein, gp100 (the antigen recognized by HMB-45), tyrosinase (T311), Melan-A
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Articles

Immunohistochemistry: Current Applications in Skin Cancer

Immunohistochemistry (IHC) techniques and applications have greatly improved, dermatopathology is still largely based on H&E stained slides.This paper outlines ways in which IHC antibodies can be utilized for dermatopathology.

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