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271M-1

Sigma-Aldrich

Inhibin, alpha (R1) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

R1, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (271M-14)
vial of 0.5 mL concentrate (271M-15)
bottle of 1.0 mL predilute (271M-17)
vial of 1.0 mL concentrate (271M-16)
bottle of 7.0 mL predilute (271M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:5-1:100

isotype

IgG2a

control

adrenal cortex

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... INHA(3623)

General description

Anti–inhibin alpha is an antibody against a peptide hormone which has demonstrated utility in the differentiation between adrenal cortical tumors and renal cell carcinoma. Sex cord stromal tumors of the ovary as well as trophoblastc tumors also demonstrate cytoplasmic positivity with this antibody. This antibody has been used to make the differential diagnosis of intrauterine vs. ectopic pregnancy in endometrial curettings.

Quality


IVD
IVD
IVD
RUO

Linkage

Inhibin, alpha Positive Control Slides, Product No. 271S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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P A Fetsch et al.
Cancer, 87(3), 168-172 (1999-06-29)
Anti-alpha-inhibin, an antibody directed against a peptide hormone, has been shown to be a useful diagnostic aid in surgical pathology material for the identification of sex cord-stromal neoplasms and recently has been described in adrenocortical carcinoma (ACC). The diagnosis of
T J Pelkey et al.
Human pathology, 30(1), 26-31 (1999-01-29)
Placental trophoblasts are the primary source of serum inhibin during pregnancy. We sought to characterize inhibin immunolabeling in trophoblastic neoplasms and compare the results with those for established markers of trophoblastic differentiation. Formalin-fixed, paraffin-embedded tissues from three normal term placentas
W G McCluggage
Journal of clinical pathology, 53(5), 327-334 (2000-07-13)
This leader reviews recent advances in immunohistochemistry that are useful in the diagnosis of ovarian neoplasms. These include the value of different anticytokeratin antibodies in the distinction between a primary ovarian adenocarcinoma and a metastatic adenocarcinoma, especially of colorectal origin.
C J Stewart et al.
Histopathology, 31(1), 67-74 (1997-07-01)
Inhibin is a heterodimeric protein hormone which appears to be a sensitive serological and immunohistochemical marker of ovarian granulosa cell tumours. The purposes of this study were to examine inhibin immunoreactivity in a wide range of gonadal stromal neoplasms and
L M Munro et al.
The Journal of endocrinology, 161(2), 341-347 (1999-05-13)
Inhibins and activins are dimeric proteins of the transforming growth factor-beta superfamily which have been shown to be expressed in the adrenal cortex. Recent studies have suggested a role for these peptides in the pathogenesis and/or function of adrenal tumours.
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