ABT330
Anti-TSLP Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
TSLP Antibody, Thymic stromal lymphopoietin
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... TSLP(85480)
General description
Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. TSLP is expressed in a number of tissues including heart, liver, and prostate.
Specificity
This antibody recognizes the intermediate domain of TSLP.
Immunogen
Epitope: Intermediate domain
KLH-conjugated linear peptide corresponding to the intermediate domain of human TSLP.
Application
Detect Thymic stromal lymphopoietin using this rabbit polyclonal antibody, Anti-TSLP Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TSLP in human prostate cancer and heart tissues.
Immunofluorescence Analysis: A 20 μg/mL from a representative lot detected TSLP in human brain cells.
Immunofluorescence Analysis: A 20 μg/mL from a representative lot detected TSLP in human brain cells.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
Quality
Evaluated by Western Blotting in A20 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected TSLP in 15 µg of A20 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected TSLP in 15 µg of A20 cell lysate.
Target description
~23 kDa observed. The calculated molecular weight of this protein is 18 kDa, but can be observed at ~23 kDa due to high glycosylation.
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
A20 cell lysate
A20 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Kathleen M Buchheit et al.
The Journal of allergy and clinical immunology, 137(5), 1566-1576 (2015-12-23)
Prostaglandin (PG) D2 is the dominant COX product of mast cells and is an effector of aspirin-induced respiratory reactions in patients with aspirin-exacerbated respiratory disease (AERD). We evaluated the role of the innate cytokine thymic stromal lymphopoietin (TSLP) acting on
Simon G Royce et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(5), 6402-6411 (2019-02-16)
The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid
Simon G Royce et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(5), 6402-6411 (2019-02-16)
The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid
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