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Merck

Biased signalling is an essential feature of TLR4 in glioma cells.

Biochimica et biophysica acta (2016-11-05)
Marie-Theres Zeuner, Carmen L Krüger, Katharina Volk, Karen Bieback, Graeme S Cottrell, Mike Heilemann, Darius Widera
RESUMO

A distinct feature of the Toll-like receptor 4 (TLR4) is its ability to trigger both MyD88-dependent and MyD88-independent signalling, culminating in activation of pro-inflammatory NF-κB and/or the antiviral IRF3. Although TLR4 agonists (lipopolysaccharides; LPSs) derived from different bacterial species have different endotoxic activity, the impact of LPS chemotype on the downstream signalling is not fully understood. Notably, different TLR4 agonists exhibit anti-tumoural activity in animal models of glioma, but the underlying molecular mechanisms are largely unknown. Thus, we investigated the impact of LPS chemotype on the signalling events in the human glioma cell line U251. We found that LPS of Escherichia coli origin (LPS

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Meio de Eagle modificado por Dulbecco - alto teor de glicose, With 4500 mg/L glucose and sodium bicarbonate, without L-glutamine and sodium pyruvate, liquid, sterile-filtered, suitable for cell culture, suitable for hybridoma
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ECL Western Blotting Analysis System, Cytiva RPN2108
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