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Merck
  • Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine.

Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine.

Organic & biomolecular chemistry (2014-10-31)
Yuko Murakami, Rina Suzuki, Hiroto Yanuma, Jiangtao He, Shuren Ma, Gerard M Turino, Yong Y Lin, Toyonobu Usuki
PMID25355397
RESUMO

Desmosine-CH2, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH2 was also achieved.

MATERIAIS
Número do produto
Marca
Descrição do produto
164194
Sigma-Aldrich
Ácido heptafluorobutírico, 98%
77249
Sigma-Aldrich
Ácido heptafluorobutírico, ≥99.0% (GC)
52411
Supelco
Ácido heptafluorobutírico, suitable for ion chromatography, ≥99.5% (GC)
49540
Supelco
Heptafluorobutyric acid solution, 0.5 M in H2O, LiChropur™, suitable for ion pair chromatography