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  • Differentiation in a rat PC12 cell line induced by ostruthin and (-)-bornyl ferulate, constituents of a Chinese herbal medicine.

Differentiation in a rat PC12 cell line induced by ostruthin and (-)-bornyl ferulate, constituents of a Chinese herbal medicine.

Bioscience, biotechnology, and biochemistry (1999-09-29)
J Qi, M Ojika, Y Sakagami
RESUMO

A search for neuritogenic compounds in Chinese herbs resulted in the isolation of two known substances, ostruthin and (-)-bornyl ferulate, from Notopterygium incisum (and/or N. forbesii). Both compounds induced comparable neurite-like structures in 20% of rat PC12 cells at 2 micrograms/ml, and showed cytotoxicity at concentrations higher than 3 micrograms/ml.

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6-Geranyl-7-hydroxycoumarin, ≥95% (LC/MS-ELSD)