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Merck

Noninvasive in vivo percutaneous absorption measurements using X-ray fluorescence.

Pharmaceutical research (1992-11-01)
J D Robertson, E Ferguson, M Jay, D J Stalker
RESUMO

X-ray fluorescence (XRF) has been used to determine in vivo the percutaneous absorption of 5-iodouracil (5IU) in dimethyl sulfoxide (DMSO) on female Sprague-Dawley rats. An average absorption rate constant of 122 +/- 34 micrograms/cm2-hr was obtained from the XRF measurements on four rats. A comparative study was performed with radiolabeled (125I) 5IU in which the absorption rate constant was determined to be 126 +/- 20 micrograms/cm2-hr. The XRF system described provides a simple, noninvasive means of measuring the percutaneous absorption rate of select compounds by the surface disappearance method.

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Sigma-Aldrich
5-Iodouracil, 98%