- Replication-Competent Influenza B Reporter Viruses as Tools for Screening Antivirals and Antibodies.
Replication-Competent Influenza B Reporter Viruses as Tools for Screening Antivirals and Antibodies.
Journal of virology (2015-09-25)
Benjamin O Fulton, Peter Palese, Nicholas S Heaton
PMID26401044
RESUMO
Influenza B virus is a human pathogen responsible for significant health and economic burden. Research into this pathogen has been limited by the lack of reporter viruses. Here we describe the development of both a replication-competent fluorescent influenza B reporter virus and bioluminescent influenza B reporter virus. Furthermore, we demonstrate these reporter viruses can be used to quickly monitor viral growth and permit the rapid screening of antiviral compounds and neutralizing antibodies.
MATERIAIS