- Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin.
Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin.
Bioorganic & medicinal chemistry letters (2007-12-11)
Santhosh Sivaramakrishnan, Kent S Gates
PMID18068362
RESUMO
Though less potent than the parent natural product leinamycin, S-deoxyleinamycin displays activity against human cancer cell lines that is comparable to many clinically used agents. The results reported here suggest that the 1,2-dithiolan-3-one heterocycle found in S-deoxyleinamycin reacts with thiols to generate a persulfide intermediate (RSS(-)) that could deliver biologically active polysulfides, hydrogen sulfide, and reactive oxygen species (O2*-, H(2)O(2), and HO*) to the interior of cells.