- Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation.
Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation.
Chemical communications (Cambridge, England) (2008-11-15)
David P Smith, Jon Anderson, Jeffrey Plante, Alison E Ashcroft, Sheena E Radford, Andrew J Wilson, Martin J Parker
PMID19009062
RESUMO
The separative and analytical power of ion mobility spectrometry-mass spectrometry combined with photo-induced cross-linking of site-specifically incorporated trifluoromethyldiazirine provides a powerful approach towards structural characterisation of amyloid fibrils.