V900351
5-Fluorocytosine
Vetec™, reagent grade, 99%
Sinônimo(s):
4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine
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About This Item
Fórmula empírica (Notação de Hill):
C4H4FN3O
Número CAS:
Peso molecular:
129.09
Beilstein:
127285
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
grau
reagent grade
linha de produto
Vetec™
Ensaio
99%
pf
298-300 °C (dec.) (lit.)
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
NC1=NC(=O)NC=C1F
InChI
1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
chave InChI
XRECTZIEBJDKEO-UHFFFAOYSA-N
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Ações bioquímicas/fisiológicas
Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.
Informações legais
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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In our previous works, we demonstrated that human neural stem cells (NSCs) transduced with the cytosine deaminase (CD) gene showed remarkable 'bystander killer effect' on glioma and medulloblastoma cells after administration of the prodrug 5-fluorocytosine (5-FC). In addition, herpes simplex
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To investigate whether hypoxia targeted bifunctional suicide gene expression-cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT) with 5-FC treatments can enhance radiotherapy. Stable transfectants of R3327-AT cells were established which express a triple-fusion-gene: CD, UPRT and monomoric DsRed (mDsRed) controlled by
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