X1629

Anti-XPG (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Anti-COFS3, Anti-ERCC5, Anti-ERCM2, Anti-UVDR, Anti-XPGC
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• reatividade de espécies: human
• concentração: ~1 mg/mL
• técnica(s): indirect immunofluorescence: 2-4 μg/mL using HEK-293T cells expressing recombinant XPG fusion protein, fixed with paraformaldehyde-Triton; western blot: 1-2 μg/mL using whole cell lysates of COS7 cells expressing recombinant XPG fusion protein
• nº de adesão UniProt: P28715
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... ERCC5(2073)

Descrição

Descrição geral

Anti-XPG (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to amino acids 1120-1137 of human XPG, conjugated to KLH via an N-terminal added cysteine residue. Xeroderma pigmentosum group G (XPG) is a DNA repair gene, that is mapped to human chromosome13q33. It is a member of the FEN-1 family of structure-specific nucleases and contains two highly conserved nuclease motifs known as the N and I regions separated by a large insertion. This gene spans around 69kb in length and has15 exons. It is highly polymorphic.

Imunogênio

synthetic peptide corresponding to amino acids 1120-1137 of human XPG, conjugated to KLH via an N-terminal added cysteine residue.

Aplicação

Anti-XPG (C-terminal) antibody produced in rabbit has been used in:

• staining cells for xeroderma pigmentosum group G (XPG) detection
• immunoblotting
• immunofluorescence

Ações bioquímicas/fisiológicas

Xeroderma pigmentosum group G (XPG) helps to maintain genomic stability. It also participates in RNA transcription by interacting with TFIIH, RNA polymerase II and Gadd45a. XPG also participates in nucleotide excision repair (NER) pathway. Mutations in the XPG gene cause the Cockayne syndrome which is characterized by severe growth defects, mental retardation and cachexia.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)