V4514
Anti-Vesicle Associated Membrane Protein 4, (VAMP4) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
reatividade de espécies
human, rat, mouse
técnica(s)
indirect immunofluorescence: 10 μg/mL using CV-1 cells
western blot: 2 μg/mL
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... VAMP4(8674)
mouse ... Vamp4(53330)
rat ... Vamp4(364033)
Descrição geral
Vesicle associated membrane protein 4 (VAMP4) is localized on human chromosome 1q24-q25. It is expressed in the skeletal muscle and liver. The protein is part of the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) family. VAMP4 is localized to the trans-Golgi network.
Especificidade
Anti-Vesicle Associated Membrane Protein 4 detectsVAMP-4.
Imunogênio
recombinant rat VAMP-4.
Ações bioquímicas/fisiológicas
Vesicle associated membrane protein 4 (VAMP4) mediates trans-Golgi network trafficking of membrane-bound and secreted proteins. Studies have shown that VAMP4 has a role in maintaining the structure of the Golgi apparatus.
forma física
Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Akiko Shitara et al.
Molecular biology of the cell, 30(3), 324-332 (2018-12-13)
Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model
Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish
Mona MS et al
Molecular Genetics and Metabolism, 85(2), 133-139 null
VAMP4 is required to maintain the ribbon structure of the Golgi apparatus
Akiko S et al.
Molecular and Cellular Biochemistry (2013)
Vera Kreykenbohm et al.
European journal of cell biology, 81(5), 273-280 (2002-06-18)
Two mammalian proteins, vtila and vtilb, are homologous to the yeast Q-SNARE Vtilp which is part of several SNARE complexes in different transport steps. In vitro experiments suggest distinct functions for vtila and vtilb. Here we compared the subcellular localization
M Steegmaier et al.
Molecular biology of the cell, 10(6), 1957-1972 (1999-06-08)
The trans-Golgi network (TGN) plays a pivotal role in directing proteins in the secretory pathway to the appropriate cellular destination. VAMP4, a recently discovered member of the vesicle-associated membrane protein (VAMP) family of trafficking proteins, has been suggested to play
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