T6515

Cholecystokinin Fragment 30-33 Amide

≥95% (HPLC)

• Sinônimo(s): CCK-4, Gastrin Tetrapeptide, Tetragastrin, Trp-Met-Asp-Phe amide
• Fórmula empírica (Notação de Hill): C₂₉H₃₆N₆O₆S
• Número CAS: 1947-37-1
• Peso molecular: 596.70
• Número MDL: MFCD00076492
• Código UNSPSC: 12352202
• ID de substância PubChem: 24900382
• NACRES: NA.32

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥95% (HPLC)
• Formulário: powder
• peso molecular: 59670 g/mol
• técnica(s): toxicology assay: suitable
• solubilidade: DMF: 20 mg/mL, clear, colorless to yellow
• adequação: suitable for molecular biology
• nº de adesão UniProt: P06307; P30553
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
• InChI: 1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1
• chave InChI: RGYLYUZOGHTBRF-BIHRQFPBSA-N
• Informações sobre genes: human ... CCK(885) ; rat ... Cckbr(25706)

Descrição

Amino Acid Sequence

Trp-Met-Asp-Phe-NH2

Descrição geral

Research area: Neuroscience

Several biologically active fragments of the neuropeptide cholecystokinin (CCK) are present in the brain, where they interact with CCK-A and CCK-B receptors. Among these fragments, CCK-4 is notably abundant in the cortical and limbic brain structures. CCK-4, a bioactive form of cholecystokinin, is a peptide hormone that regulates food intake by binding to CCK receptors in the gut and brain.

Aplicação

Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera.Cholecystokinin Fragment 30-33 Amide has been used to induce anxiolytic- and antidepressant-like effects and study the role of neuropeptide Y, in mice.

Ações bioquímicas/fisiológicas

Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing new anxiolytic drugs.CCK-4 acts selectively through CCK-B receptors and is recognized for its role in regulating emotional behaviors. Studies on CCK knock-down mice have indicated anxiolytic- and antidepressant-like effects.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota de preparo

Cholecystokinin Fragment 30-33 Amide dissolves in Dimethylformamide at 20 mg/ml to yield a clear, colorless to yellow solution.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)