T4680

Terazosin hydrochloride

≥98% (TLC), powder

• Sinônimo(s): 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride
• Fórmula empírica (Notação de Hill): C₁₉H₂₅N₅O₄ · HCl
• Número CAS: 63074-08-8
• Peso molecular: 423.89
• Número MDL: MFCD00467965
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278740
• NACRES: NA.77

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥98% (TLC)
• forma: powder
• cor: white to off-white
• solubilidade: H₂O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow; methanol: 20 mg/mL, clear, colorless; ethanol: 4 mg/mL
• originador: Abbott
• cadeia de caracteres SMILES: Cl[H].COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4
• InChI: 1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
• chave InChI: IWSWDOUXSCRCKW-UHFFFAOYSA-N
• Informações sobre genes: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Descrição

Descrição geral

Terazosin hydrochloride is used to treat hypertension and benign prostatic hyperplasia (BPH). It is metabolised in the liver. It might be associated with dizziness, headache and asthenia. Terazosin hydrochloride is linked to acute generalized exanthematous pustulosis.

Aplicação

Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies⁵. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods⁶.

Ações bioquímicas/fisiológicas

α₁-adrenoceptor antagonist.

Características e benefícios

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota de preparo

Terazosin hydrochloride is soluble in water at 19.60 - 20.40 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol at 4 mg/ml. Furthermore, the product is soluble in methanol at 20 mg/ml, with heat as needed, and yields a clear, colorless solution.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves