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SRP6171

IL-3 human

Name: IL-3 human
Brand: SIGMA

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinônimo(s):

HCGF, MGC79398, Mast cell growth factor (MCGF), Multi-CSF, P-cell stimulation factor

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About This Item

Código UNSPSC:

12352202

fonte biológica

human

recombinante

expressed in HEK 293 cells

Ensaio

≥95% (SDS-PAGE)

Formulário

lyophilized

peso molecular

17-45 kDa (monomer, glycosylated)

embalagem

pkg of 10 μg

técnica(s)

cell culture | mammalian: suitable

nº de adesão NCBI

P08700

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... IL3(3562)

Descrição geral

IL3 is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It stimulates colony formation of megakaryocytes, neutrophils, and macrophages from bone marrow cultures. It is also involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

forma física

Lyophilized from a PBS solution.

Nota de preparo

Centrifuge the vial prior to opening.

Reconstituição

Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Lot/Batch Number

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Basophils exhibit antibacterial activity through extracellular trap formation.

S Yousefi et al.

Allergy, 70(9), 1184-1188 (2015-06-05)

Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report

Low-dose decitabine promotes megakaryocyte maturation and platelet production in healthy controls and immune thrombocytopenia.

Hai Zhou et al.

Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)

Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production

Genuine Immunomodulation With dSLIM.

Kerstin Kapp et al.

Molecular therapy. Nucleic acids, 3, e170-e170 (2014-06-25)

Toll-like receptors are sensing modulators of the innate immune system. One member of this protein family, Toll-like receptor (TLR)-9, is increasingly being investigated as therapeutic target for infectious diseases and cancer. Double-Stem Loop ImmunoModulator (dSLIM) is a new TLR-9 agonist

Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity.

Amy H Lin et al.

Journal of virology, 88(17), 10066-10077 (2014-06-27)

We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host

Breast Cancer Cell-Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes.

Cristina Ghirelli et al.

Cancer research, 75(14), 2775-2787 (2015-05-16)

Reciprocal interactions between tumor cells and their microenvironment vitally impact tumor progression. In this study, we show that GM-CSF produced by primary breast tumor cells induced the activation of plasmacytoid predendritic cells (pDC), a cell type critical to anti-viral immunity.

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