SRP6062
PP2C α human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Sinônimo(s):
PP1A, PP2CA, PPM1A, Protein phosphatase 1A
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Produtos recomendados
fonte biológica
human
recombinante
expressed in E. coli
Ensaio
≥95% (SDS-PAGE)
forma
liquid
peso molecular
46.6 kDa (418aa)
embalagem
pkg of 100 μg
nº de adesão NCBI
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... PPM1A(5494)
Descrição geral
Protein phosphatase 2C-α (PP2C-α), also referred to as protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the family of Ser/Thr protein phosphatases. It is characterized with a catalytic subunit and a constant regulatory subunit. PP2C-α is abundantly expressed in heart and skeletal muscle.
Ações bioquímicas/fisiológicas
Protein phosphatase 2C-α (PP2C-α) is known to be a negative regulator of cell stress response pathways. Additionally, it has been reported to negatively regulate transforming growth factor-β (TGF-β) signaling pathway and cell cycle. PP2C-α has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion.
Sequência
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWILMGAF LDKPKMEKHN AQGQGNGLRY GLSSMQGWRV EMEDAHTAVI GLPSGLESWS FFAVYDGHAG SQVAKYCCEH LLDHITNNQD FKGSAGAPSV ENVKNGIRTG FLEIDEHMRV MSEKKHGADR SGSTAVGVLI SPQHTYFINC GDSRGLLCRN RKVHFFTQDH KPSNPLEKER IQNAGGSVMI QRVNGSLAVS RALGDFDYKC VHGKGPTEQL VSPEPEVHDI ERSEEDDQFI ILACDGIWDV MGNEELCDFV RSRLEVTDDL EKVCNEVVDT CLYKGSRDNM SVILICFPNA PKVSPEAVKK EAELDKYLEC RVEEIIKKQG EGVPDLVHVM RTLASENIPS LPPGGELASK RNVIEAVYNR LNPYKNDDTD STSTDDMW
forma física
1 mg/mL solution in 10 mM Tris-HCl, pH 7.5, 50 mM NaCl, 2 mM DTT, 1 mM MnCl2, 20% glycerol.
Nota de preparo
Centrifuge the vial prior to opening.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Irrit. 2
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway.
Geng J, et al.
Oncotarget, 5(14), 5700-5711 (2014)
Integrated analysis of expression and genome alteration reveals putative amplified target genes in esophageal cancer.
Takashi S, et al.
Oncology Letters, 18(2), 465-472 (2007)
PPM1A Methylation Is Associated With Vascular Recurrence in Aspirin-Treated Patients.
Gallego-Fabrega C, et al.
Stroke, 47(7), 1926-1929 (2016)
Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Cα and β2 isoforms.
Cheng A, et al.
The Journal of Biological Chemistry, 275(44), 34744-34749 (2000)
Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.
Mazur S J, et al.
Biochemistry, 56(21), 2676-2689 (2017)
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica