SRP5308

c-KIT (T670E), active, GST tagged human

PRECISIO^®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Sinônimo(s): CD117, PBT, SCFR
• Código UNSPSC: 12352200
• NACRES: NA.32

Propriedades

• recombinante: expressed in baculovirus infected Sf9 cells
• linha de produto: PRECISIO^®
• Ensaio: ≥70% (SDS-PAGE)
• forma: buffered aqueous glycerol solution
• atividade específica: 3.8-5.8 nmol/min·mg
• peso molecular: ~73 kDa
• nº de adesão NCBI: NM_000222
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... KIT(3815)

Descrição

Descrição geral

c-KIT (T670E) is the human homolog of the proto-oncogene c-kit which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. c-KIT (T670E) is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-KIT (T670E) function in hematopoiesis, melanogenesis, and gametogenesis and mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. c-KIT (T670E) signaling is involved in human skin pigmentation and that this signaling pathway is regulated by sKIT. It is also help in regulating primordial germ cell growth.

forma física

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Nota de preparo

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Informações legais

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable