SRP4972

GHBP human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Sinônimo(s): GH receptor, GHBP, GHR, Somatotropin receptor
• Código UNSPSC: 12352200
• NACRES: NA.32

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥98% (SDS-PAGE)
• Formulário: lyophilized
• peso molecular: ~28.1 kDa
• embalagem: pkg of 50 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• Impurezas: endotoxin, tested
• nº de adesão NCBI: P10912
• nº de adesão UniProt: P10912

Descrição

Descrição geral

GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.
The gene encoding growth hormone receptor (GHR or GHBP) is localized on human chromosome 5p13.1-p12, with nine exons. It possesses a cytoplasmic and an extracellular domain for protein binding.

forma física

GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO3.

Reconstituição

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in sterile dH₂O not less than 100 μg/ml. This solution can then be diluted into other aqueous buffers.