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Merck
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Documentos Principais

SRP4908

Sigma-Aldrich

Visfatin

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Sinônimo(s):

Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog

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About This Item

Código UNSPSC:
12352200

fonte biológica

mouse

recombinante

expressed in E. coli

Ensaio

≥95% (HPLC)
≥95% (SDS-PAGE)

forma

lyophilized

peso molecular

~55.0 kDa

embalagem

pkg of 10 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

Impurezas

endotoxin, tested

nº de adesão NCBI

Q99KQ4

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... Nampt(59027)

Descrição geral

Visfatin is also called pre-B cell colony enhancing factor, nicotinamide phosphoribosyltransferase, pre-B-cell colony-enhancing factor 1 homolog, NAmPRTase, Nampt and PBEF. Visfatin is an adipocytokine produced by visceral fat.

Ações bioquímicas/fisiológicas

Visfatin has a role in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis. Studies have shown that mice deficient in visfatin in the forebrain excitatory neurons show hyperactivity, diminished anxiety-like behaviors and impaired learning and memory. It has also been shown that visfatin stimulates glucose uptake and adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in mouse C2C12 skeletal muscle cells.

forma física

Lyophilized without any additives.

Reconstituição

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in PBS to the concentration of 0.1-1 mg/mL.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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The evolutionary portrait of metazoan NAD salvage.
Carneiro J
PLoS ONE, 8(5), e64674-e64674 (2013)
Visfatin, a novel adipokine, stimulates glucose uptake through the Ca2 +-dependent AMPK-p38 MAPK pathway in C2C12 skeletal muscle cells.
Lee JO
Journal of Molecular Endocrinology, 54(3), 251-262 (2015)
Liana Roberts Stein et al.
Brain research bulletin, 119(Pt A), 41-51 (2015-10-21)
Nicotinamide adenine dinucleotide (NAD(+)) is an essential coenzyme/cosubstrate for many biological processes in cellular metabolism. The rate-limiting step in the major pathway of mammalian NAD(+) biosynthesis is mediated by nicotinamide phosphoribosyltransferase (Nampt). Previously, we showed that mice lacking Nampt in
Jiawen Yong et al.
Journal of cellular and molecular medicine, 25(20), 9710-9723 (2021-09-16)
Hypoxia-induced apoptosis of cementoblasts (OCCM-30) may be harmful to orthodontic treatment. Hypoxia-inducible factor 1-alpha (HIF-1α) mediates the biological effects during hypoxia. Little is known about the survival mechanism capable to counteract cementoblast apoptosis. We aimed to investigate the potential roles
Yuri L Boteon et al.
PloS one, 13(7), e0201419-e0201419 (2018-07-26)
Pharmacological defatting of rat hepatocytes and hepatoma cell lines suggests that the same method could be used to ameliorate macrovesicular steatosis in moderate to severely fatty livers. However there is no data assessing the effects of those drugs on primary
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