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Key Documents

SRP2146

Sigma-Aldrich

CAR, GST tagged, human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

Sinônimo(s):

CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.26

fonte biológica

human

recombinante

expressed in E. coli

Ensaio

≥70% (SDS-PAGE)

forma

frozen liquid

peso molecular

~66.3 kDa

embalagem

pkg of 10 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

concentração

350 μg/mL

cor

clear
 colorless

nº de adesão NCBI

NM_005122

nº de adesão UniProt

Q14994

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... NR1I3(9970)

Ações bioquímicas/fisiológicas

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively acitve, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

forma física

Clear and colorless frozen liquid solution

Nota de preparo

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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P Wei et al.
The pharmacogenomics journal, 2(2), 117-126 (2002-06-07)
The products of the cytochrome P450 (CYP) genes play an important role in the detoxification of xenobiotics and environmental contaminants, and many foreign chemicals or xenobiotics can induce their expression. We have previously shown that the nuclear hormone receptor CAR
M Baes et al.
Molecular and cellular biology, 14(3), 1544-1552 (1994-03-01)
We have identified and characterized a new orphan member of the nuclear hormone receptor superfamily, called MB67, which is predominantly expressed in liver. MB67 binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor
P Wei et al.
Nature, 407(6806), 920-923 (2000-11-01)
Organisms encounter a wide range of foreign compounds--or 'xenobiotics'--with potentially harmful consequences. The cytochrome P450 (CYP) enzymes metabolize xenobiotics and thus are a primary defence against these compounds. Increased expression of specific CYP genes in response to particular xenobiotics is

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