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Key Documents

SRP2116

Sigma-Aldrich

RNA Polymerase II, p15.6 subunit, GST tagged human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Sinônimo(s):

HRBP14.4, POLRF, RPABC2, RPB14.4, RPB6

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.26

fonte biológica

human

recombinante

expressed in E. coli

Ensaio

≥85% (SDS-PAGE)

forma

frozen liquid

peso molecular

~40 kDa

embalagem

pkg of 10 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

concentração

200 μg/mL

cor

clear colorless

nº de adesão NCBI

NM_021974

nº de adesão UniProt

P61218

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... POLR2F(5435)

Ações bioquímicas/fisiológicas

hRPB6 is a highly conserved subunit shared by all three RNA polymerases, consisting of 142 amino acid residues. The gene for yeast RPB6 is essential for cell viability and homologues of this subunit exist in archaeal and some viral RNA polymerases. For example the bacterial w (the fifth subunit of the bacterial RNAP core enzyme) and eukaryotic RPB6 are structural homologs. RPB6 has been shown to promote pol II complex assembly, and/or increase its stability, through specific interactions with the largest subunit of RNA pol II. In addition, RPB6 was found to make contact with three small subunits, RPB5, RPB7, and RPB8 and to play a role in the interaction between RNA polymerase II and the transcription elongation factor TFIIS.

forma física

Clear and colorless frozen liquid solution

Nota de preparo

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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L Minakhin et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(3), 892-897 (2001-02-07)
Bacterial DNA-dependent RNA polymerase (RNAP) has subunit composition beta'betaalpha(I)alpha(II)omega. The role of omega has been unclear. We show that omega is homologous in sequence and structure to RPB6, an essential subunit shared in eukaryotic RNAP I, II, and III. In
A Ishiguro et al.
Molecular and cellular biology, 20(4), 1263-1270 (2000-01-29)
The Rpb6 subunit of RNA polymerase II is one of the five subunits common to three forms of eukaryotic RNA polymerase. Deletion and truncation analyses of the rpb6 gene in the fission yeast Schizosaccharomyces pombe indicated that Rpb6, consisting of
N A Woychik et al.
Genes & development, 4(3), 313-323 (1990-03-01)
RNA polymerases I, II, and III share three subunits that are immunologically and biochemically indistinguishable. The Saccharomyces cerevisiae genes that encode these subunits (RPB5, RPB6, and RPB8) were isolated and sequenced, and their transcriptional start sites were deduced. RPB5 encodes

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