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Key Documents

SRP2068

Sigma-Aldrich

SRC1, His tagged, TEV site, human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Sinônimo(s):

F-SRC-1, KAT13A, MGC129719, MGC129720, RIP160, SRC1, bHLHe42, bHLHe74

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.26

fonte biológica

human

recombinante

expressed in E. coli

Ensaio

≥80% (SDS-PAGE)

forma

frozen liquid

peso molecular

~19.5 kDa

embalagem

pkg of 10 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

concentração

400 μg/mL

cor

clear colorless

nº de adesão NCBI

NM_003743

nº de adesão UniProt

Q15788

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... NCOA1(8648)

Ações bioquímicas/fisiológicas

Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 has been shown to be over expressed in some cancers. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptorsand have been previously used in assays detecting ligand-dependent receptor-cofactor interactions. This protein contains the Tobacco Etch virus (TEV) protease site and can be cleaved using acTEV to yield untagged SRC1 RID. This protein will be useful for assays where a native untagged protein is desired.

forma física

Clear and colorless frozen liquid solution

Nota de preparo

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Toshihiko Yanase et al.
Internal medicine (Tokyo, Japan), 43(5), 368-373 (2004-06-23)
Coregulators are a group of proteins, which modulate the nuclear receptor transactivation function. In this study, a new "coregulator disease" concept was proposed from observations of a case of androgen insensitivity syndrome (AIS) and cases involving Rubinstein-Taybi syndrome and X-linked
S A Oñate et al.
Science (New York, N.Y.), 270(5240), 1354-1357 (1995-11-24)
A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of the promoter. Because the protein stimulated transactivation of all the steroid receptors

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