SRP2067

CAR, ligand binding domain (101-348) human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

• Sinônimo(s): CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• Código UNSPSC: 12352202
• NACRES: NA.26

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥85% (SDS-PAGE)
• Formulário: frozen liquid
• peso molecular: ~30 kDa
• embalagem: pkg of 10 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• concentração: 500 μg/mL
• cor: clear; colorless
• nº de adesão NCBI: NM_005122
• nº de adesão UniProt: Q14994
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... NR1I3(9970)

Descrição

Ações bioquímicas/fisiológicas

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by `phenobarbitol-like` compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

forma física

Clear and colorless frozen liquid solution

Nota de preparo

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable