SRP0339
Ceramide Kinase FLAG tag active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥40% (SDS-PAGE)
Sinônimo(s):
CERK, LK4, hCERK
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
fonte biológica
human
recombinante
expressed in baculovirus infected Sf9 cells
Ensaio
≥40% (SDS-PAGE)
Formulário
aqueous solution
peso molecular
60 kDa
embalagem
pkg of 10 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
concentração
0.4 mg/mL
nº de adesão NCBI
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... CERK(64781)
Descrição geral
Ceramide kinase (CERK) is a 537-amino acid protein. It has a catalytic region, a putative amino-myristoylation site in its amino terminal region and a pleckstrin homology domain. The gene encoding CERK is localized on human chromosome 22q13.31.
Human ceramide kinase (CERK) (GenBank Accession No. NM_022766), 1-537 (end) with C-terminal Flag-tag, MW= 60 kDa, expressed in Baculovirus expression system.
Aplicação
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Ações bioquímicas/fisiológicas
Ceramide kinase (CERK) is an enzyme involved in sphingolipid metabolism and in the synthesis of ceramide-1-phosphate. It associates with calmodulin and at the time of Fc receptor-mediated phagocytosis, it aggregates in lipid rafts. CERK may have a role in calcium signaling. The protein functions in the phagocytosis of polymorphonuclear leukocytes and degranulation of mast cells.
Definição da unidade
One unit is defined as the amount of enzyme required to produce 1 pmole of ceramide-1-phosphate/min at 37°C.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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A conserved cysteine motif essential for ceramide kinase function
Lidome E, et al.
Biochimie, 90(10), 1560-1565 (2008)
Ceramide kinase: a novel lipid kinase molecular cloning and functional characterization
Sugiura M, et al.
The Journal of Biological Chemistry (2002)
Identification of genes associated with tumorigenesis of retinoblastoma by microarray analysis
Chakraborty S, et al.
Genomics, 90(3), 344-353 (2007)
Tack-Joong Kim et al.
Biochemical and biophysical research communications, 342(2), 611-617 (2006-02-21)
Ceramide kinase (CERK) converts ceramide to ceramide-1-phosphate (C1P), which has recently emerged as a new bioactive molecule capable of regulating diverse cellular functions. The N-terminus of the CERK protein encompasses a sequence motif known as a pleckstrin homology (PH) domain.
Tomomi Date et al.
In vitro cellular & developmental biology. Animal, 43(10), 321-323 (2007-10-25)
Ceramide kinase (CerK) has important roles in leukocyte functions, including the role in degranulation of mast cells and the phagocytosis of polymorphonuclear leukocytes, so its expression levels should be strictly regulated. Here, we report that the mRNA expression and enzyme
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