SML3281

GSK215 hydrochloride

≥98% (HPLC)

• Sinônimo(s): (2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-(4-(2-(methylcarbamoyl)phenylamino)-5-(trifluoromethyl)pyridin-2-ylamino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride, GSK 215 hydrochloride, GSK-215 hydrochloride
• Fórmula empírica (Notação de Hill): C₅₀H₅₉F₃N₁₀O₆S · xHCl
• Peso molecular: 985.13 (free base basis)
• Número MDL: MFCD34574613
• Código UNSPSC: 51111800
• Código UNSPSC: 12352200
• NACRES: NA.21

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• composição: , 0-8 (H2O); , 1.8-3.3 mol (HCl)
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear (warmed)
• temperatura de armazenamento: 2-8°C

Descrição

Ações bioquímicas/fisiológicas

GSK215 is a potent and selective focal adhesion kinase (FAK) degrader (DC50 = 1.3 nM; A549 cells) composed of the FAK inhibitor VS-4718 and the VHL E3 ligase binder VHL-021. GSK215 shows cell type-dependent growth inhibition, where it inhibits A549 (IC50 <1 µM) and MCF-7 (IC50 <0.1 µM), but not BT474, in 2D cultures, while the growth of BT47 (IC50 <0.1 µM) and MCF-7 (IC50 ~0.1 µM), but not A5494, are inhibited by GSK215 in 3D cultures.

Atenção

Hygroscopic

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable