SML3213

Lobaplatin

≥98% (NMR)

• Sinônimo(s): Cis-[trans-1,2-cyclobutanebis(methylamine)-N,N′]-[(2S)-lactate-O1,O2)-platinum (II), D 19466, D-19466, D19466, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,kN′][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)-platinum, trans-1,2-Cyclobutanedimethanamine, platinum complex
• Fórmula empírica (Notação de Hill): C₉H₁₈N₂O₃Pt
• Número CAS: 135558-11-1
• Peso molecular: 397.33
• Código UNSPSC: 12352107
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (NMR)
• forma: powder
• cor: white to beige
• solubilidade: H₂O: 2 mg/mL, clear (Warmed)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C1[O-][Pt+2]2(N[CH2]C3CCC3CN2)[O-]C1C
• InChI: 1S/C6H12N2.C3H5O3.Pt/c7-3-5-1-2-6(5)4-8;1-2(4)3(5)6;/h5-8H,1-4H2;2H,1H3,(H,5,6);/q-2;-1;+4/p-1/t;2-;/m.0./s1
• chave InChI: HADHSETVEMCBPU-TYOUJGAFSA-M

Descrição

Ações bioquímicas/fisiológicas

Lobaplatin (D-19466) is a third-generation platinum anticancer agent in vitro and in vivo, consisting of ~50:50 mixture of the two trans-1,2-cyclobutanedimethanamine diastereomers in complex with L-lactic acid. Llobaplatin shows antitumor efficacy against various human cancer cancer xenografts and significantly prolongs the survival of mice bearing P388 leukemia (mean life span increase post single i.p. in mg/kg = 46%/4.64 & 77/14.7). Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable