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SML2797

Sigma-Aldrich

UNBS5162

≥98% (HPLC)

Sinônimo(s):

N-[2-[2-(Dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]urea, UNBS 5162, [2-[2-(Dimethylamino)ethyl]-1,3-dioxobenzo[de]isoquinolin-5-yl]urea

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About This Item

Fórmula empírica (Notação de Hill):
C17H18N4O3
Número CAS:
956590-23-1
Peso molecular:
326.35
Número MDL:
MFCD22380608
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 2 mg/mL, clear

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[n]1([c](c2c3c([c]1=O)cccc3cc(c2)NC(=O)N)=O)CCN(C)C

InChI

1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24)

chave InChI

WCKZRLOUKYFJDY-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

UNBS5162, an amonafide (naphthalimide) derivative, is a potent antitumor agent that inhibits tumor proliferation, progression and invasiveness. UNBS5162 is a pan-antagonist of CXCL chemokine expression. It appears that UNBS5162 inhibits melanoma progression through inhibition of the AKT/mTOR signaling pathway.
pan-antagonist of CXCL chemokine expression

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Tatjana Mijatovic et al.
Neoplasia (New York, N.Y.), 10(6), 573-586 (2008-06-03)
Several naphthalimides have been evaluated clinically as potential anticancer agents. UNBS3157, a naphthalimide that belongs to the same class as amonafide, was designed to avoid the specific activating metabolism that induces amonafide's hematotoxicity. The current study shows that UNBS3157 rapidly
Xin Yue et al.
Experimental and therapeutic medicine, 16(5), 3921-3928 (2018-10-23)
UNBS5162, a naphthalimide derivative, has a strong anticancer effect and low clinical hematological toxicity. UNBS5162 has been shown to have an anticancer effect in numerous cancer types, except triple negative breast cancer (TNBC). To explore this issue, TNBC MDA-MB-231 cells
Yingyi Ye et al.
Cancer management and research, 11, 2339-2348 (2019-04-10)
Human melanoma is a malignant tumor originated from melanocytes with high invasion, metastasis, and poor prognosis. In this study, the effects of naphthalimides UNBS5162 and amonafide on the properties of proliferation and apoptosis in human melanoma cells were confirmed. Cell

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