SML1740
FIN56
≥98% (HPLC)
Sinônimo(s):
N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
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About This Item
Fórmula empírica (Notação de Hill):
C25H31N3O5S2
Número CAS:
Peso molecular:
517.66
Código UNSPSC:
12352200
NACRES:
NA.77
Nível de qualidade
Ensaio
≥98% (HPLC)
forma
powder
cor
white to beige
solubilidade
DMSO: 20 mg/mL, clear
temperatura de armazenamento
room temp
Ações bioquímicas/fisiológicas
FIN56 is a specific inducer of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). FIN56 has an EC50 value of 240 nM, and is believed to act though two separate pathways. The first requires the enzymatic activity of acetyl-CoA carboxylase (ACC),and results in degradation of glutathione peroxidase 4 (GPX4), which acts as a negative regulator of ferroptosis by reducing lipid hydroperoxides. The second pathway involves FIN56 binding to and activing squalene synthase, which leads to coenzyme Q10 depletion.
Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Unsolved mysteries: How does lipid peroxidation cause ferroptosis?.
Feng H and Stockwell BR
PLoS Biology, 16(5), e2006203-e2006203 (2018)
Po-Han Chen et al.
Cell death and differentiation, 27(3), 1008-1022 (2019-07-20)
Ferroptosis is a specialized iron-dependent cell death that is associated with lethal lipid peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been implicated in various human diseases as well as potential antitumor activities. However, much remains unknown
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