SML1669

NCX 4016

≥98% (HPLC)

• Sinônimo(s): 2-(Acetyloxy)-benzoic acid 3-[(nitrooxy)methyl]phenyl ester, 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester, 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate, NCX-4016, Nitroaspirin
• Fórmula empírica (Notação de Hill): C₁₆H₁₃NO₇
• Número CAS: 175033-36-0
• Peso molecular: 331.28
• Número MDL: MFCD01939436
• Código UNSPSC: 51111800
• ID de substância PubChem: 329826004
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: DMSO: 25 mg/mL, clear
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CC(OC1=CC=CC=C1C(OC2=CC(CO[N+]([O-])=O)=CC=C2)=O)=O
• InChI: 1S/C16H13NO7/c1-11(18)23-15-8-3-2-7-14(15)16(19)24-13-6-4-5-12(9-13)10-22-17(20)21/h2-9H,10H2,1H3
• chave InChI: IOJUJUOXKXMJNF-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

NCX 4016 (nitroaspirin) is nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor. NCX 4016 improves postischemic ventricular dysfunction and to reduce myocardial infarct size in rabbit.

NCX-4016 can prevent the progression of cisplatin-resistant human ovarian cancer xenografts in mice. It can also regulate the expression of B-cell lymphoma 2 (Bcl-2) proteins in ovarian cancer cells. Hence, NCX-4016 is considered a promising therapeutic option against carcinoma.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable